業績

原著論文など

最近の論文 2011年 2010年 2009年 2008年 2007年 2006年 2005年 2004年 2003年 2002年 小泉(-2001) 吉永(-2001) ホームに戻る

2017
原著論文
In press. RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease
Matsuda Y, Mineharu Y, Kimura M, Takagi Y, Kobayashi H, Hitomi T, Harada KH, Uchihashi Y, Funaki T, Miyamoto S, Koizumi A.
J Stroke Cerebrovasc Dis. Accepted 13 Apr, 2017. doi:
4. Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A.
PLOS One. 12(4):e0175649, 2017. doi: 10.1371/journal.pone.0175649
3. Major determinants for selection of antithrombotic therapies in patients with non-valvular atrial fibrillation in Japan (JAPAF study)
Koichi Kusakawa, Kouji H Harada, Tatsuo Kagimura, Akio Koizumi
J Arrhythmia. Accepted 24 Jun, 2016; 33(2):99-106, 2017. doi: 10.1016/j.joa.2016.06.006
2. Long-term Trends in Dietary Intake of Perfluoroalkyl Carboxylic Acids in Relation to their Serum Concentration in two regions in Japan from 1979 to 2011
Yukiko Fujii, Kouji H Harada, Koichi Haraguchi, Akio Koizumi
Chemosphere. Accepted 13 February, 176:165-174, 2017 doi: 10.1016/j.chemosphere.2017.02.073
1. Lactational exposure to short-chain chlorinated paraffins in China, Korea and Japan
Yang Cao, Kouji H. Harada, Toshiaki Hitomi, Tamon Niisoe, Peiyu Wang, Yuhui Shi, Hye-Ran Yang, Takumi Takasuga and Akio Koizumi
Chemosphere. Accepted 17 Dec, 2016; 173: 43-48, 2017. doi: 10.1016/j.chemosphere.2016.12.078
総説・解説等
1. 小児四肢疼痛発作症
野口篤子、奥田裕子、小林果、小泉昭夫、高橋勉
日本臨床 75巻4号:641-651. 2017年4月
2016
原著論文
12. Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples
Koichi Haraguchi, Yoshiko Ito, Masae Takagi, Yukiko Fujii, Kouji H. Harada, Akio Koizumi
Environ. Int. Accepted 25 Aug, 97: 155-162, 2016 doi: 10.1016/j.envint.2016.08.022
11. RNF213 is associated with Intracranial Aneurysms in the French-Canadian population
Sirui Zhou, Amirthagowri Ambalavanan, Daniel Rochefort, Pingxing Xie, Cynthia V. Bourassa, Pascale Hince, Alexandre Dionne-Laporte, Dan Spiegelman, Ziv Gan-Or, Cathy Mirarchi, Vessela Zaharieva, Nicolas Dupre, Hatasu Kobayashi, Toshiaki Hitomi, Kouji Harada, Akio Koizumi, Lan Xiong, Patrick A. Dion, Guy A. Rouleau
Am J Hum Genet. Available online on 13 Oct, 99(5): 1072-1085, 2016 doi: 10.1016/j.ajhg.2016.09.001
10. Significant association of the RNF213 p.R4810K polymorphism with quasi-moyamoya disease
Takaaki Morimoto, Yohei Mineharu, Hatasu Kobayashi, Kouji H. Harada, Takeshi Funaki, Yasushi Takagi, Nobuyuki Sakai, Susumu Miyamoto, Akio Koizumi
J Stroke Cerebrovasc Dis. Accepted 2 Jul, 25(11): 2632-2636, 2016. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.004
9. RNF213 rare variants in Slovakian and Czech moyamoya disease patients
Hatasu Kobayashi, Miroslav Brozman, Katerina Kyselova, Dasa Viszlayova, Takaaki Morimoto, Martin Roubec, David Skoloudik, Andrea Petrovicova, Dominik Juskanic, Jozef Strauss, Marian Halaj, Peter Kurray, Marian Hranai, Kouji H Harada, Sumiko Inoue, Yukako Yoshida, Toshiyuki Habu, Roman Herzig, Shohab Youssefian, Akio Koizumi
PLOS ONE. Accepted 6 Oct., 11(10): e0164759, 2016. doi: 10.1371/journal.pone.0164759
8. Frequency of RNF213 p.R4810K, a susceptibility variant for moyamoya disease, and health characteristics of carriers in the Japanese population
Yang Cao, Hatasu Kobayashi, Takaaki Morimoto, Risako Kabata, Kouji H. Harada, Akio Koizumi
Environ Health Prev Med. Accepted 24 Jun, 21(5): 387-390, 2016 doi: 10.1007/s12199-016-0549-8
7. Spatial and Temporal Trends in Perfluorooctanoic and Perfluorohexanoic Acid in Well, Surface, and Tap Water around a Fluoropolymer Plant in Osaka, Japan
Yoko Shiwaku; Pureum Lee; Phayong Thepaksorn; Bo Zheng; Akio Koizumi; Kouji H Harada
Chemosphere. Accepted 2 September, 164: 603-610, 2016 doi: 10.1016/j.chemosphere.2016.09.006
6. Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models
Tomonaga Ameku, Daisuke Taura, Masakatsu Sone, Tomohiro Numata, Masahiro Nakamura, Fumihiko Shiota, Taro Toyoda, Satoshi Matsui, Toshikazu Araoka, Tetsuhiko Yasuno, Shin-Ichi Mae, Hatasu Kobayashi, Naoya Kondo, Fumiyo Kitaoka, Naoki Amano, Sayaka Arai, Tomoko Ichisaka, Norio Matsuura, Sumiko Inoue, Takuya Yamamoto, Kazutoshi Takahashi, Isao Asaka, Yasuhiro Yamada, Yoshifumi Ubara, Eri Muso, Atsushi Fukatsu, Akira Watanabe, Yasunori Sato, Tatsutoshi Nakahata, Yasuo Mori, Akio Koizumi, Kazuwa Nakao, Shinya Yamanaka, Kenji Osafune
Sci Rep. Published online 15 July, 6: 30013, 2016. doi: 10.1038/srep30013
5. Lifestyle-related diseases following the evacuation after the Fukushima Daiichi Nuclear Power Plant accident: a retrospective study of Kawauchi village with long-term follow-up
Daniel K Ebner, Megumi Ohsawa, Keiko Igari, Kouji H. Harada, Akio Koizumi
BMJ Open. Accepted 20 Jun, 6: e011641, 2016. doi: 10.1136/bmjopen-2016-011641
4. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.
Nat Cell Biol. Available online Jun 20, 18(7): 803-813, 2016 doi: 10.1038/ncb3376
3. Infantile pain episodes associated with novel Nav1.9 mutations in familial episodic pain syndrome in Japanese families
Hiroko Okuda, Atsuko Noguchi, Hatasu Kobayashi, Daiki Kondo, Kouji H. Harada, Shohab Youssefian, Hirotomo Shioi, Risako kabata, Yuki Domon, Kazufumi Kubota, Yutaka Kitano, Yasunori Takayama, Toshiaki Hitomi, Kousaku Ohno, Yoshiaki Saito, Takeshi Asano, Makoto Tominaga, Tsutomu Takahashi, and Akio Koizumi
PLOS ONE. Accepted 22 Apr, 11(4): e0154827, 2016. doi: 10.1371/journal.pone.0154827
2. Neonicotinoid concentrations in urine from chronic kidney disease patients in the North Central Region of Sri Lanka
Risako Kabata, Shanika Nanayakkara, STMLD Senevirathna, Kouji H. Harada, Rohana Chandrajith, Toshiaki Hitomi, Tilak Abeysekera, Takumi Takasuga and Akio Koizumi
J. Occup. Health. Accepted 7 Oct, 2015; 58(1): 128-133, 2016. doi: 10.1539/joh.15-0140-BR
1. Biological monitoring of human exposure to neonicotinoids using urine samples, and neonicotinoid excretion kinetics
Kouji H. Harada, Keiko Tanaka, Hiroko Sakamoto, Mie Imanaka, Tamon Niisoe, Toshiaki Hitomi, Hatasu Kobayashi, Hiroko Okuda, Sumiko Inoue, Koichi Kusakawa, Masayo Oshima, Kiyohiko Watanabe, Makoto Yasojima, Takumi Takasuga, and Akio Koizumi
PLOS ONE. Accepted 20 Dec, 2015; 11(1): e0146335, 2016. doi: 10.1371/journal.pone.0146335
総説・解説等
1. A new horizon of Moyamoya disease and associated health risks explored by RNF213
Akio Koizumi, Hatasu Kobayashi, Toshiaki Hitomi, Kouji H Harada, Toshiyuki Habu, Shohab Youssefian
Environ Health Prev Med. Accepted 19 Nov, 2015; 21(2): 55-70, 2016 doi: 10.1007/s12199-015-0498-7
1. 産業保健における脳血管障害
松田和郎、小泉昭夫
産業医学ジャーナル 39巻1号:74-79. 2016年1月
2. Fukushima - fünf Jahre danach
Georg Steinhauser, Akio Koizumi
Physik Journal 15(3): 39-43, 2016
2015
原著論文
12. Temporal Levels of Urinary Neonicotinoid and Diaklyphosphate Concentrations in Japanese Women Between 1994-2011
Jun Ueyama, Kouji H Harada, Akio Koizumi, Yuka Sugiura, Takaaki Kondo, Isao Saito, and Michihiro Kamijima
Environ Sci Technol. Accepted 10 Nov, 49(24): 14522-14528, 2015 doi: 10.1021/acs.est.5b03062
11. Post-accident sporadic releases of airborne radionuclides from the Fukushima Daiichi nuclear power plant site
Georg Steinhauser, Tamon Niisoe, Kouji H Harada, Katsumi Shozugawa, Stephanie Schneider, Hans Arno Synal, Clemens Walther, Marcus Christl, Kenji Nanba, Hirohiko Ishikawa, and Akio Koizumi
Environ Sci Technol. Accepted 8 Oct, 49(24): 14028-14035, 2015 doi: 10.1021/acs.est.5b03155
10. Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka
Nanayakkara S, Senevirathna S, Parahitiyawa NB, Abeysekera T, Chandrajith R, Ratnatunga N, Hitomi T, Kobayashi H, Harada KH, Koizumi A
Environ Health Prev Med. Accepted 5 June, 20(5):354-9, 2015 doi: 10.1007/s12199-015-0475-1
9. Early onset of moyamoya syndrome in a Down syndrome patient with the genetic variant RNF213 p.R4810K
Pin Fee Chong, Reina Ogata, Hatasu Kobayashi, Akio Koizumi, Ryutaro Kira
Brain Dev. Available online 26 December 2014; 37(8):822-824, 2015 doi: 10.1016/j.braindev.2014.12.006
8. Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.
Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Habu T, Takagi Y, Miyamoto S, Koizumi A.
J Am Heart Assoc. 4(7): e002146, 2015 doi: 10.1161/JAHA.115.002146
7. Short-chain chlorinated paraffins in cooking oil and related products from China
Yang Cao; Kouji H Harada; Wanyang Liu; Junxia Yan; Can Zhao; Tamon Niisoe; Ayumu Adachi; Yukiko Fujii; Chihiro Nouda; Takumi Takasuga; Akio Koizumi
Chemosphere. Accepted 21 May, 138: 104-111, 2015 doi: 10.1016/j.chemosphere.2015.05.063
6. Perfluorinated carboxylic acids discharged from the Yodo River Basin, Japan
Tamon Niisoe; S.T.M.L.D. Senevirathna; Kouji H Harada; Yukiko Fujii; Toshiaki Hitomi; Hatasu Kobayashi; Junxia Yan; Can Zhao; Masayo Oshima; Akio Koizumi
Chemosphere. Accepted 22 May, 138: 81-88, 2015 doi: 10.1016/j.chemosphere.2015.05.060.
5. The importance of molecular diagnosis in the accurate diagnosis of systemic carnitine deficiency
Toshiaki Hitomi, Norio Matsuura, Yosuke Shigematsu, Yoshiyuki Okano, Eri Shinozaki, Masahiko Kawai, Hatasu Kobayashi, Kouji H. Harada, Akio Koizumi 
J Genet. Accepted 23 Sept, 2014; 94(1): 147-150, 2015 doi: 10.1007/s12041-015-0486-0
4. Genetic Study of Intracranial Aneurysms
Junxia Yan, Toshiaki Hitomi, Katsunobu Takenaka, Masayasu Kato, Hatasu Kobayashi, Hiroko Okuda, Kouji H. Harada, Akio Koizumi
Stroke. Accepted on Dec 26, 2014; 46(3): 620-626, 2015 doi: 10.1161/STROKEAHA.114.007286
3. Toxicokinetics of perfluoroalkyl carboxylates with different carbon chain lengths in mice and humans
Yukiko Fujii, Tamon Niisoe, Kouji H. Harada, Shinji Uemoto, Yasuhiro Ogura, Katsunobu Takenaka, Akio Koizumi
J. Occup. Health. Accepted 15 Sept, 2014; 57(1): 1-12, 2015 doi: 10.1539/joh.14-0136-OA
2. Long-chain perfluoroalkyl carboxylic acids in Pacific cods from coastal areas in northern Japan: a major source of human dietary exposure
Yukiko Fujii, Tsukasa Sakurada, Kouji H. Harada, Akio Koizumi, Osamu Kimura, Tetsuya Endo, Koichi Haraguchi
Environ. Poll. Accepted 6 Jan; 199: 35-41, 2015 doi: 10.1016/j.envpol.2015.01.007
1. Pentafluorobenzyl esterification of haloacetic acids in tap water for simple and sensitive analysis by gas chromatography/mass spectrometry with negative chemical ionization
Can Zhao, Yukiko Fujii, Junxia Yan, Kouji H. Harada, Akio Koizumi
Chemosphere. Accepted 18 July, 2014; 119: 711-718, 2015 doi: 10.1016/j.chemosphere.2014.07.048
1. 生合成経路阻害に関連したヒト血清中グリシンの窒素同位体比異常
武蔵 正明、廣野留都、伊永隆史、原田浩二、小泉昭夫
安定同位体と生体ガス: 医学応用 7巻1号:20-27. 2015年11月
総説・解説等
1. 子どもを取り巻く環境と健康(第4回) 環境化学物質の曝露
有機フッ素系化学物質 (PFCs) の曝露実態
原田浩二、小泉昭夫
公衆衛生 79巻6号:413-418. 2015年6月
2. 生まれ変わる日本の社会医学(座談会)
小泉昭夫、磯博康、渡邊昌
医と食 7巻3号:119-127. 2015年6月
2014
原著論文
6. Methylmercury Monitoring Study in Karakuwacho, a Peninsula Area in Japan
Junxia Yan, Kayoko Inoue, Akihiro Asakawa, Kouji H. Harada, Takao Watanabe, Noriyuki Hachiya, Akio Koizumi
Bull. Environ. Contam. Toxicol. Accepted 23 Feb, 93(1): 36-41, 2014 doi: 10.1007/s00128-014-1241-6
5. Radiation dose rates now and in the future for residents neighboring restricted areas of Fukushima Daiichi Nuclear Power Plant
Harada KH, Niisoe T, Imanaka M, Takahashi T, Amako K, Fujii Y, Kanameishi M, Ohse K, Nakai Y, Nishikawa N, Saito Y, Sakamoto H, Ueyama K, Hisaki K, Ohara E, Inoue T, Yamamoto K, Matsuoka Y, Ohata H, Toshima K, Okada A, Sato H, Kuwamori T, Tani H, Suzuki R, Kashikura M, Nezu M, Miyachi Y, Arai F, Kuwamori M, Harada S, Ohmori A, Ishikawa H and Koizumi A
Proc Natl Acad Sci USA. Online released 24 Feb, 111(10): E914-923, 2014 doi: 10.1073/pnas.1315684111
4. An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka
Nanayakkara S, Senevirathna STMLD, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne EDL, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A
J. Occup. Health. Accepted 4 Oct, Online released 18 Dec, 2013; 56(1): 28-38, 2014 doi: 10.1539/joh.13-0172-OA
3. Detection of Antibodies to Human T-Cell Leukemia Virus Types 1 and 2 in Breast Milk from East Asian Women
Matsubara F, Sagara Y, Kato Y, Harada K, Koizumi A, Haraguchi K.
Biol. Pharm. Bull. Accepted 29 Oct, 2013; 37(2):311-314, 2014 doi: 10.1248/bpb.13-00558
2. Temporal trend and age-dependent serum concentration of phenolic organohalogen contaminants in Japanese men during 1989--2010
Fujii Y, Harada KH, Hitomi T, Kobayashi H, Koizumi A, Haraguchi K.
Environ. Poll. Accepted 10 Nov, 2013; 185: 228-233, 2014 doi: 10.1016/j.envpol.2013.11.002
1. Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentrations in breast milk and serum in Japan
Fujii Y, Nishimura E, Kato Y, Harada KH, Koizumi A, Haraguchi K.
Environ. Int. Accepted 25 Oct, 2013; 63(1): 19-25, 2014 doi: 10.1016/j.envint.2013.10.016
1. 福島県川内村産食品の放射性セシウム137の調理の下処理前の含量および下処理による減少率
桑守豊美、宮地洋子、桑守正範、原田澄子、大森聡、原田浩二、小泉昭夫
仁愛大学研究紀要 人間生活学部篇 (6), 15-20, 2014
総説・解説
1. もやもや病とRNF213遺伝子
小林果、人見敏明、小泉昭夫
分子脳血管病 13巻2号:54-56. 2014年7月
2013
原著論文
14. Genome-wide association study identifies no major founder variant in Caucasian moyamoya disease
Wanyang Liu, STMLD Senevirathna, Toshiaki Hitomi, Hatasu Kobayashi, Constantin Roder, Roman Herzig, Markus Kraemer, Maurits H J Voormolen, Pavlina Cahova, Boris Krischek and Akio Koizumi
J Genet. Accepted 25 Jul, 92(3): 605-609, 2013 doi: 10.1007/s12041-013-0304-5
13. Rapid Progression of Unilateral Moyamoya Disease in a Patient with a Family History and an RNF213 Risk Variant
Mineharu Y, Takagi Y, Takahashi JC, Hashikata H, Liu W, Hitomi T, Kobayashi H, Koizumi A, Miyamoto S.
Cerebrovasc Dis. 36(2): 155-157, 2013 doi: 10.1159/000352065
12. The moyamoya disease susceptibility variant RNF213 R4810K induces genomic instability by mitotic abnormality
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
Biochem Biophys Res Commun. Available online 27 Aug, 439(4): 419-426, 2013 doi: 10.1016/j.bbrc.2013.08.067
11. Levels of urinary isoflavones and lignan polyphenols in Japanese women
Liu W, Tanabe M, Harada KH, Koizumi A.
Environ. Health Prev. Med. Accepted 29 March, 18(5): 394-400, 2013 doi: 10.1007/s12199-013-0338-6
10. Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells
Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM
Am. J. Physiol. Endocrinol. Metab. Accepted 1 July, 305(5):E585-99, 2013 doi:10.1152/ajpendo.00093.2013
9. 137Cs trapped by biomass within 20 km of the Fukushima Daiichi Nuclear Power Plant
Koizumi A, Niisoe T, Harada KH, Fujii Y, Adachi A, Hitomi T, Ishikawa H.
Environ Sci Technol. Accepted 26 Jul, 47(17): 9612-9618, 2013 doi: 10.1021/es401422g
8. Occurrence of perfluorinated carboxylic acids (PFCAs) in personal care products and compounding agents
Fujii Y, Harada KH, Koizumi A.
Chemosphere. Accepted 18 Jun, 93(3): 538-544, 2013 doi: 10.1016/j.chemosphere.2013.06.049
7. Downregulation of Securin by the variant RNF213 R4810K reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients
Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
Biochem Biophys Res Commun. Accepted 2 Jul, 438(1):13-19, 2013 doi: 10.1016/j.bbrc.2013.07.004
6. Combined linkage analysis and exome sequencing identifies novel genes for familial goiter
Yan JX, Takahashi T, Ohura T, Adachi A, Takahashi I, Ogawa E, Okuda H, Kobayashi H, Hitomi T, Liu WY, Harada KH, Koizumi A
J Hum Genet. Accepted 25 Feb, 58(6): 366-377, 2013 doi: 10.1038/jhg.2013.20
5. Exome sequencing identifies a new candidate mutation for susceptibility to diabetes in a family with highly aggregated type 2 diabetes
Tanaka D, Nagashima K, Sasaki M, Funakoshi S, Kondo Y, Yasuda K, Koizumi A, Inagaki N.
Mol. Genet. Metabol. Accepted 13 Feb, 109(1): 112-117, May 2013 doi: 10.1016/j.ymgme.2013.02.010
4. Dietary Intake of Radiocesium in Adult Residents in Fukushima Prefecture and Neighboring Regions after the Fukushima Nuclear Power Plant Accident: 24 hr-Food Duplicate Survey in December 2011
Harada KH, Fujii Y, Adachi A, Tsukidate A, Asai F, Koizumi A
Environ Sci Technol. Accepted 24 Dec, 2012; 47(6):2520-2526, March 19, 2013 doi: 10.1021/es304128t
3. Ablation of Rnf213 retards progression of diabetes in the Akita mouse
Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A
Biochem Biophys Res Commun. Accepted 4 Feb, 432(3):519-525, March 15, 2013 doi:10.1016/j.bbrc.2013.02.015
2. P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure.
Koizumi A, Kobayashi H, Liu W, Fujii Y, Senevirathna ST, Nanayakkara S, Okuda H, Hitomi T, Harada KH, Takenaka K, Watanabe T, Shimbo S.
Environ. Health Prev. Med. Accepted 26 July, 2012; 18(2):121-9, March 2013 doi: 10.1007/s12199-012-0299-1
1. Polyfluorinated telomers in indoor air of Japanese houses
Liu W, Takahashi S, Sakuramachi Y, Harada KH, Koizumi A.
Chemosphere. Accepted 7 Sept, 2012; 90 (5): 1672-1677, February 2013 doi: 10.1016/j.chemosphere.2012.09.062
1. 未治療高血圧患者に対するテルミサルタン(ミカルディス錠)の有効性と安全性の検討
西村誠一郎, 草川浩一, 秋元孝文, 奥村広之, 中村一郎, 鍵村達夫, 小泉昭夫
血圧 20巻8号:818-26. 2013年8月 J-GLOBAL ID: 201302220677842525
Correspondence
1. Protein S K196E mutation, a genetic risk factor for venous thromboembolism, is limited to Japanese.
Wanyang Liu, Tong Yin, Hiroko Okuda, Kouji H Harada, Yang Li, Bin Xu, Jie Yang, Hongjuan Wang, Xinping Fan, Akio Koizumi, Toshiyuki Miyata
Thromb. Res. Accepted 5 May, 132(2): 314-315, 2013 doi: 10.1016/j.thromres.2013.05.008
Editorial
1. Occupational Health for Well-being, Dignity, and Creativity
Akio Koizumi
Ind Health, 51(4): 371-372, 2013 doi: 10.2486/indhealth.400
総説・解説
3. もやもや病の遺伝子変異
小林果、人見敏明、小泉昭夫
Clinical Neuroscience 31巻12号:1456-1457. 2013年12月
2. もやもや病感受性遺伝子mysterinにおける日中韓で共通な創始者多型と人類学的考察
小泉昭夫, 小林果
DNA多型. 21巻 1-7, 2013
1. もやもや病感受性遺伝子の特定
小林果, 人見敏明, 小泉昭夫
BioClinica. 28巻1号 87-91, 2013
著書・訳書
1. Handbook of dietary and nutritional aspects of human breast milk: Prevention, treatment and toxicity
edited by: Sherma Zibadi, Ronald Ross Watson and Victor R. Preedy, 2013 Apr, Wageningen Academic Publishers. ISBN 978-90-8686-209-2
Akio Koizumi, Kouji Harada, Yukiko Fujii. Comparing pesticides in human breast milk from China, Korea and Japan. pp 743-758.
2012
原著論文
13. Analysis of perfluoroalkyl carboxylic acids in composite dietary samples by gas chromatography/mass spectrometry with electron capture negative ionization
Fujii Y, Harada KH, Koizumi A.
Environ Sci Technol. Accepted 18 Sept; available online 3 Oct; 46(20): 11235-11242, October 16, 2012 doi: 10.1021/es302536g
12. Patient-Specific Modeling and Multi-Scale Blood Simulation for Computational Hemodynamic Study on the Human Cerebrovascular System
Oshima M, Torii R, Tokuda S, Yamada S, Koizumi A.
Curr Pharm Biotechnol. Accepted 9 September, 2011; 13(11):2153-65, 2012 doi: 10.2174/138920112802502105
11. Clinical features of SCA36: A novel spinocerebellar ataxia with motor neuron involvement (Asidan)
Ikeda Y, Ohta Y, Kobayashi H, Okamoto M, Takamatsu K, Ota T, Manabe Y, Okamoto K, Koizumi A, Abe K..
Neurology. Published online June 27, 79(4): 333-341, July 24, 2012 doi:10.1212/WNL.0b013e318260436f
10. Comparative survey of levels of chlorinated cyclodiene pesticides in breast milk from some cities of China, Korea and Japan
Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi K.
Chemosphere. Available online 27 June, 89(4): 452-457, October 2012 doi: 10.1016/j.chemosphere.2012.05.098
9. Cognitive and affective impairments of a novel SCA/MND crossroad mutation Asidan
Abe K, Ikeda Y, Kurata T, Ohta Y, Manabe Y, Okamoto M, Takamatsu K, Ohta T, Takao Y, Shiro Y, Shoji M, Kamiya T, Kobayashi H, Koizumi A.
Eur J Neurol. Published online 21 Feb, 19(8): 1070-1078, August 2012 doi: 10.1111/j.1468-1331.2012.03669.x
8. Preliminary assessment of ecological exposure of adult residents in Fukushima prefecture to radioactive cesium through ingestion and inhalation
Koizumi A, Harada KH, Niisoe T, Adachi A, Fujii Y, Hitomi T, Kobayashi H, Wada Y, Watanabe T, Ishikawa H.
Environ. Health Prev. Med. Accepted 23 Oct, 2011; 17(4): 292-298, July 2012 doi: 10.1007/s12199-011-0251-9 [和文翻訳]
7. Tubulointerstitial damage as the major pathological lesions in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka
Nanayakkara S, Komiya T, Ratnatunga N, Senevirathna STMLD, Harada KH, Hitomi T, Gobe G, Muso E, Abeysekera T, KoizumiA, Chronic Kidney Disease of Uncertain Aetiology Consortium
Environ. Health Prev. Med. Accepted 16 Sept, 2011; 17(3): 213-221, May 2012 doi: 10.1007/s12199-011-0243-9
6. Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain aetiology: a cohort study in Medawachchiya, Sri Lanka: A cohort study
Senevirathna STMLD, Abeysekera T, Nanayakkara S, Chandrajith R, Ratnatunga N, Harada KH, Hitomi T, Komiya T, Muso E, KoizumiA, Chronic Kidney Disease of Uncertain Aetiology Consortium
Environ. Health Prev. Med. Accepted 8 Aug, 2011; 17(3): 191-198, May 2012 doi: 10.1007/s12199-011-0237-7
5. Distribution of Moyamoya Disease Susceptibility Polymorphism p.R4810K in RNF213 in East and Southeast Asian Populations
Liu W, Hitomi T, Kobayashi H, Harada KH, KoizumiA.
Neurol. Med. Chir. Accepted 1 Feb, 2012; 52(5): 299-303, May 25, 2012 doi:10.2176/nmc.52.299
4. Screening for Antibodies to Human T-Cell Leukemia Virus Type I in Japanese Breast Milk
Matsubara F, Haraguchi K, Harada K, KoizumiA.
Biol. Pharm. Bull. Accepted 1 Feb, 2012; 35(5): 773-776, May 01, 2012 doi: 10.1248/bpb.35.773
3. Evidence of tubular damage in the very early stage of chronic kidney disease of uncertain aetiology in the North Central Province of Sri Lanka: a cross sectional study
Nanayakkara S, Senevirathna STMLD, Karunaratne U, Chandrajith R, Harada KH, Hitomi T, Watanabe T, Abeysekera T, Aturaliya TNV, KoizumiA, Chronic Kidney Disease of Uncertain Aetiology Consortium
Environ. Health Prev. Med. Accepted 30 May, 2011; 17(2): 109-117, March 2012 doi: 10.1007/s12199-011-0224-z
2. Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia
Fujii Y, Yan J, Harada KH, Hitomi T, Yang H, Wang P, Koizumi A.
Chemosphere. Accepted 21 Oct, 2011; 86(3): 315-321, January 2012 doi: 10.1016/j.chemosphere.2011.10.035
1. Regional variation and possible sources of brominated contaminants in breast milk from Japan
Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi K.
Environ. Poll. Accepted 16 Nov, 2011; 162:269-274, March 2012 doi: 10.1016/j.envpol.2011.11.022
5. 高血圧患者に対するテルミサルタン(ミカルディス錠)の40mg/日から80mg/日への増量による降圧効果の検討 Japanese Telmisartan Study for Antihypertensive Good Effect in Long Term Observation(J-TARGET)
草川 浩一, 秋元 孝文, 奥村 広之, 中村 一郎, 鍵村 達夫, 小泉 昭夫
血圧 19巻12号:1157-1165. 2012年12月 J-GLOBAL ID:201202211402357272
4. 慢性腎臓病(CKD)合併高血圧患者に対するテルミサルタン(ミカルディス錠)長期投与時の降圧効果と脳・心血管系イベント発生状況,安全性に関する検討
下澤達雄, 鍵村達夫, 小泉昭夫
血圧 19巻3号:289-299. 2012年3月 J-GLOBAL ID: 201202297123346858
3. 高齢者高血圧患者に対するテルミサルタン(ミカルディス錠)長期投与時の降圧効果ならびに脳・心血管系イベント発生状況,安全性に関する検討
小泉昭夫, 原田浩二, 鍵村達夫,
血圧 19巻3号:275-288. 2012年3月 J-GLOBAL ID: 201202212636466519
2. メタボリックシンドローム合併高血圧患者に対するテルミサルタンの有効性と安全性
寺本民生, 鍵村達夫, 小泉昭夫
血圧 19巻2号:180-189. 2012年2月 J-GLOBAL ID: 201202281279415775
1. 糖尿病合併高血圧患者に対するテルミサルタン(ミカルディス(R)錠)長期投与時の降圧効果と脳・心血管イベント発生に関する検討
河盛隆造, 鍵村達夫, 小泉昭夫
血圧 19巻1号:65-73. 2012年1月 J-GLOBAL ID: 201202293504388446
Editorial
3. Asian forum on environmental health policy: challenges and perspectives of environmental health problems in the region in the next 30 years
Kyungho Choi, Domyung Paek, Tangchun Wu, Chang-Chuan Chan, Rattapon Onchang, Chantana Padungtod, Akio Koizumi
Environ Health Prev Med, 17(2): 170-172, Feb 2012 doi: 10.1007/s12199-012-0269-7
2. A preface to the international forum as a source of diversity opinions.
Koizumi A
Environ Health Prev Med, 17(2): 169, Feb 2012 doi: 10.1007/s12199-012-0266-x
1. A new phase transition for EHPM from a paper-based journal to an on-line one.
Koizumi A
Environ. Health Prev Med. 17(1): 1, Jan 2012 doi: 10.1007/s12199-011-0253-7
Guideline
1. Guidelines for Diagnosis and Treatment of Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis)
Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis, Health Labour Sciences Research Grant for Research on Measures for Intractable Diseases
Neurol. Med. Chir. 52(5): 245-266, May 25, 2012 doi:10.2176/nmc.52.245
総説・解説
3. Mysterin遺伝子ともやもや病
峰晴陽平, 小泉昭夫
医学のあゆみ. 242巻12号 948, 2012
2. 論壇・リスク管理の考え方の再考
小泉昭夫.
産業医学ジャーナル. 35巻4号 71-72, 2012
1. 総説 もやもや病関連遺伝子
小泉昭夫、小林果、人見敏明
脳神経外科 40巻2号:105-118. 2012年2月
著書・訳書
1. NEW予防医学・公衆衛生学 改訂第3版
岸玲子、古野純典、大前和幸、小泉昭夫 編 2012 Apr, 南江堂 ISBN 978-4-524-26315-8
2. Series モデル動物利用マニュアル…< 疾患モデルの作製と利用 糖尿病・肥満/感染症 >
第2節 2型糖尿病・肥満モデル動物 第4項 Akitaマウス(浅川明弘/小泉昭夫)
2012 July, 株式会社 エル・アイ・シー ISBN 978-4900487512
2011
原著論文
14. Analysis of perfluoroalkyl carboxylates in vacuum cleaner dust samples in Japan
Liu W, Chen S, Harada KH, Koizumi A.
Chemosphere. Accepted 24 Sept, 85(11): 1734-1741, 2011 doi: 10.1016/j.chemosphere.2011.09.024
13. Usefulness of a large automated health records database in pharmacoepidemiology
Hashikata H, Harada KH, Kagimura T, Nakamura M, Koizumi A.
Environ. Health Prev. Med. Accepted 21 Nov, 2010, 16(5): 313-319, 2011 doi: 10.1007/s12199-010-0201-y
12. Dietary exposure to short-chain chlorinated paraffins has increased in Beijing, China
Harada KH, Takasuga T, Hitomi T, Wang PY, Matsukami H, Koizumi A.
Environ Sci Technol. Accepted 20 Jul, 45(16):7019-7027, 2011 doi: 10.1021/es200576d
11. Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development
Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura, Satoru Yamazaki, Atsushi Toyoda, Ken-ichiro Kikuta, Yasushi Takagi, Kouji H Harada, Asao Fujiyama, Roman Herzig, Boris Krischek, Liping Zou, Jeong Eun Kim, Masafumi Kitakaze, Susumu Miyamoto, Kazuhiro Nagata, Nobuo Hashimoto, Akio Koizumi.
PLoS ONE. published online 20 Jul, 6(7): e22542, 2011 doi: 10.1371/journal.pone.0022542
10. Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes a Type of Spinocerebellar Ataxia (SCA36) Accompanied by Motor Neuron Involvement
Hatasu Kobayashi, Koji Abe, Tohru Matsuura, Yoshio Ikeda, Toshiaki Hitomi, Yuji Akechi, Toshiyuki Habu, Wangyang Liu, Hiroko Okuda and Akio Koizumi
Am J Hum Genet. Available online on 16 Jun, 89(1): 121-130, 2011 doi: 10.1016/j.ajhg.2011.05.015
9. Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam
Harada KH, Hitomi T, Niisoe T, Takenaka K, Kamiyama S, Watanabe T, Moon CS, Yang HR, Hung NN, Koizumi A.
Environ. Int. Accepted 17 Apr, 37(7): 1183-1189, 2011 doi: 10.1016/j.envint.2011.04.011
8. Mycotoxin Detection in Urine Samples from Patients with Chronic Kidney Disease of Uncertain Etiology in Sri Lanka
Desalegn B, Nanayakkara S, Harada KH, Hitomi T, Chandrajith R, Karunaratne U, Abeysekera T, Koizumi A.
Bull. Environ. Contam. Toxicol. Accepted 28 Apr, 87(1): 6-10, 2011 doi: 10.1007/s00128-011-0301-4
7. Chronic Kidney Diseases of Uncertain Etiology (CKDue) in Sri Lanka: geographic distribution and environmental implications
Chandrajith R, Nanayakkara S, Itai K, Aturaliya TNC, Dissanayake CB, Abeysekera T, Harada K, Watanabe T, Koizumi A
Environ Geochem Health. Accepted 1 Sept, 2010; 33(3): 267-278, 2011. doi: 10.1007/s10653-010-9339-1
6. Historical trends in human dietary intakes of endosulfan and toxaphene in China, Korea and Japan
Desalegn B, Takasuga T, Harada KH, Hitomi T, Fujii Y, Yang HR, Wang P, Senevirathna S, Koizumi A.
Chemosphere. Accepted 28 Feb, 83(10):1398-1405, 2011 doi: 10.1016/j.chemosphere.2011.02.063
5. Environmental ecological modeling of human blood lead levels in East Asia
Niisoe T, Harada KH, Hitomi T, Watanabe T, Hung NN, Ishikawa H, Wang Z, Koizumi A.
Environ Sci Technol. Accepted 9 Feb, 45(7):2856-2862, 2011 doi: 10.1021/es103666e
4. Subarachnoid hemorrhage among employees: problems in Japanese social security law
Yuki T, Koizumi A.
J. Soc. Sec. Law. Accepted 14 Nov, 2010; 18(2): 87-101, 2011 doi:
3. GCKR mutations in Japanese families with clustered type 2 diabetes
Tanaka D, Nagashima K, Sasaki M, Yamada C, Funakoshi S, Akitomo K, Takenaka K, Harada K, Koizumi A, Inagaki N.
Mol. Genet. Metabol. Accepted 16 Dec, 2010; 102(4):453-460, 2011 doi: 10.1016/j.ymgme.2010.12.009
2. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women
Mineharu Y, Koizumi A, Wada Y, Iso H, Watanabe Y, Date C, Yamamoto A, Kikuchi S, Inaba Y, Toyoshima H, Kondo T, Tamakoshi A, JACC Study Group
J Epidemiol Community Health. Accepted 20 Nov, 2009; 65(3):230-240, 2011 doi: 10.1136/jech.2009.097311
1. Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan
Fujii Y, Haraguchi K, Harada KH, Hitomi T, Inoue K, Itoh Y, Watanabe T, Takenaka K, Uehara S, Yang HR, Kim MY, Moon CS, Kim HS, Wang P, Liu A, Hung NN, Koizumi A.
Chemosphere. Accepted 11 Oct, 2010; 82:25-31, 2011 doi: 10.1016/j.chemosphere.2010.10.036
3. カルシウム拮抗薬との併用投与におけるテルミサルタン(ミカルディス錠)の降圧効果と安全性の評価
―製造販売後特定使用成績調査(J-TARGET)の結果―
草川浩一, 菅裕徳, 秋元孝文, 中村一郎, 小林俊光, 鍵村達夫, 小泉昭夫
血圧 18巻11号:1123-1129. 2011年11月 J-GLOBAL ID: 201102209700173042
2. 高血圧患者に対するテルミサルタン(ミカルディス錠)長期投与時の脳・心血管イベント発生率の検討
 Japanese Telmisartan Study for Antihypertensive Good Effect in long term observation (J-TARGET)
小室一成, 河盛隆造, 寺本民生, 鍵村達夫, 小泉昭夫
血圧 18巻10号:894-905. 2011年10月 J-GLOBAL ID: 201102296374100307
1. 高血圧患者に対するテルミサルタン(ミカルディス錠)の長期投与時の降圧効果と安全性の評価
小室一成, 河盛隆造, 寺本民生, 鍵村達夫, 小泉昭夫
血圧 18巻9号:894-905. 2011年9月 J-GLOBAL ID: 201102242377005094
Commentary
1. A Commentary on Identification of an autosomal dominant locus for intracranial aneurysm through a model-based family collection in a geographically limited area
Koizumi A
J Hum Genet, 56(7):477, 2011 doi: 10.1038/jhg.2011.57
総説・解説
1. 社会と健康を科学するパブリックヘルス(4)
コンピューターシミュレーションによる環境中化学物質のヒト曝露評価法
新添多聞、原田浩二、小泉昭夫
日本公衆衛生雑誌 58巻3号:209-211. 2011年3月
2. 日中韓における母乳を用いた残留性有機汚染物質のモニタリング
小泉昭夫、藤井由希子、新添多聞、原田浩二
日本母乳哺育学会雑誌 5巻2号:41-52. 2011年4月
3. 家族性脳動静脈奇形と遺伝子
小泉昭夫、井上純子
Clinical Neuroscience 29巻10号:1147-1150. 2011年10月
4. もやもや病の原因遺伝子の概要(Q&A)
小泉昭夫
日本医事新報 4560号:57-58. 2011年9月
2010
原著論文
11. Long-term simulation of human exposure to atmospheric perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) in the Osaka urban area, Japan
Niisoe T, Harada KH, Ishikawa H, Koizumi A.
Environ Sci Technol. Accepted 10 Sept, 44(20):7852-7857, 2010 doi: 10.1021/es101948b
10. Pediatric living-donor liver transplantation for acute liver failure: analysis of 57 cases
Mohamed El Moghazy W, Ogura Y, Minata M, Harada K, Koizumi A, Uemoto S
Transpl Int. Accepted 17 Jan, 23(8):823-830, 2010 doi: 10.1111/j.1432-2277.2010.01059.x
9. Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene.
Takahashi I, Yamada Y, Kadowaki H, Horikoshi M, Kadowaki T, Narita T, Tsuchida S, Noguchi A, Koizumi A, Takahashi T.
Endocr J. 57(6):509-516, 2010 doi: 10.1507/endocrj.K09E-339
8. Confirmation of an association of SNP rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients
Hashikata H, Liu W, Inoue K, Mineharu Y, Yamada S, Nanayakkara S, Matsuura N, Hitomi T, Takagi Y, Hashimoto N, Miyamoto S, Koizumi A.
Stroke. Accepted on Feb 15, 41(6):1138-1144, 2010 doi: 10.1161/STROKEAHA.109.576694
7. History of blood transfusion before 1990 is associated with increased risk for cancer mortality independently of liver disease: a prospective long-term follow-up study
Inoue Y, Wada Y, Motohashi Y, Koizumi A.
Environ. Health Prev Med. Accepted 19 Nov, 2009; 15(3):180-187, 2010 doi: 10.1007/s12199-009-0125-6
6. Can children catch-up growth after living-donor liver transplantation?
Elmoghazy WE, Ogura Y, Harada K, Koizumi A, Uemoto S
Liver Transpl. Accepted 29 Nov, 2009; 16(4):453-460, 2010 doi: 10.1002/lt.22010
5. A global transport model of lead in the atmosphere
Niisoe T, Nakamura E, Harada K, Ishikawa H, Hitomi T, Watanabe T, Wang Z, Koizumi A.
Atmos Environ. Accepted 7 Jan; 44(14): 1806-1814, 2010 doi: 10.1016/j.atmosenv.2010.01.001
4. Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008
Harada KH, Yang HR, Moon CS, Hung NN, Hitomi T, Inoue K, Niisoe T, Watanabe T, Kamiyama S, Takenaka K, Kim MY, Watanabe K, Takasuga T, Koizumi A.
Chemosphere. Accepted 18 Jan, 79(3):314-319, 2010 doi: 10.1016/j.chemosphere.2010.01.027
3. Spontaneous development of ER stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 (iPLA2β) expression: A role for regulation by SREBP-1
Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S
J Biol Chem. Published 23 Dec, 2009, 285(9):6693-705, 2010 doi: 10.1074/jbc.M109.084293
2. A rare Asian founder polymorphism in Raptor may explain the high prevalence of moyamoya disease in East Asian and low prevalence in Caucasian
Liu W, Hashikata H, Inoue K, Matsuura N, Mineharu Y, Kobayashi H, Kikuta KI, Takagi Y, Hitomi T, Krischek B, Zou LP, Fang F, Herzig R, Kim JE, Kang HS, Oh CW, Tregouet DA, Hashimoto N, Koizumi A.
Environ. Health Prev Med. Accepted 13 Oct, 2009; 15(2):94-104, 2010 doi: 10.1007/s12199-009-0116-7
1. Role of peroxisome proliferator-activated receptor-α in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver [preprint]
Minata M, Harada KH, Karrman A, Hitomi T, Hirosawa M, Murata M, Gonzalez FJ, Koizumi A.
Ind Health. Accepted 23 July 2009, 48:96-107, 2010 doi: 10.2486/indhealth.48.96
Commentary
1. A Commentary on genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms
Koizumi A
J Hum Genet, 55:635-636, 2010 doi: 10.1038/jhg.2010.93
総説・解説
1. より合理的なフィールド遺伝疫学をめざして
小泉昭夫
日本衛生学雑誌 65巻1号:37-47. 2010年1月 doi: 10.1265/jjh.65.37
2. もやもや病(ウイリス動脈輪閉塞症)診断・治療ガイドライン
橋本信夫, 冨永悌二, 宮本享, 永田泉, 寶金清博, 鈴木則宏, 小泉昭夫, 野川茂, 中川原譲二, 北川一夫, 黒田敏, 菊田健一郎, 藤村幹, 高橋淳, 林健太郎, 大木宏一, 星野晴彦, 高木康志
脳卒中の外科 37巻5号:321-37. 2009年9月 doi: 10.2335/scs.37.321
3. 特集・知っておきたい医療と法律
原田浩二、小泉昭夫. 公害防止のための法律
Modern Physician. 30巻10号 1334-1337, 2010
4. 随筆・第83回日本産業衛生学会 福井に参加して
小泉昭夫.
産業医学ジャーナル. 33巻6号 101-102, 2010
5. 改訂版 分子予防環境医学-生命科学研究の予防・環境医学への統合-
分子予防環境医学研究会 編 2010 Dec, 本の泉社
原田浩二、小泉昭夫「残留性有機汚染物質」:721-730.
新添多聞、小泉昭夫「生体試料バンク」:769-774.
6. 家族性発症が疑われたペラグラ脳症の1例
山口哲央、足立昌司、牧典彦、二村省三、前西修、小泉昭夫.
内科. 106巻2号 365-369, 2010
7. スリランカ民主社会主義共和国における原因不明の慢性腎不全の多発性・家族集積性に関する現地調査報告と同国の看護師4名の当院研修受け入れの報告
竹中勝信、柴田敏朗、小泉昭夫
高山赤十字病院紀要 34号:15-19. 2010年12月 医中誌文献番号: 2011126580
2009
原著論文
9. Levels and regional trend of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrated POPs signatures unique to individual countries
Haraguchi K, Koizumi A, Inoue K, Harada KH, Hitomi T, Minata M, Tanabe M, Kato Y, Nishimura E, Yamamoto Y, Watanabe T, Takenaka K, Uehara S, Yang HR, Kim MY, Moon CS, Kim HS, Wang P, Liu A, Hung NN.
Environ Int. Accepted 8 June, 35(7):1072-1079, 2009 doi: 10.1016/j.envint.2009.06.003
8. Paradoxical Increases in Serum Levels of Highly Chlorinated PCBs in Aged Women in Clear Contrast to Robust Decreases in Dietary Intakes from 1980 to 2003 in Japan
Koizumi A, Harada KH, Eslami B, Fujimine Y, Hachiya N, Hirosawa I, Inoue K, Inoue S, Koda S, Kusaka Y, Murata K, Omae K, Saito N, Shimbo S, Takenaka K, Takeshita T, Todoriki H, Wada Y, Watanabe T, Ikeda M.
Environ. Health Prev Med. Accepted 26 Apr, available online 28 May, 14(4):235-246, 2009 doi: 10.1007/s12199-009-0089-6
7. Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid
Nakagawa H, Terada T, Harada KH, Inoue K, Inui K, Koizumi A.
Basic Clin Pharmacol Toxicol. in press Jan, 105(2):136-138, 2009 doi: 10.1111/j.1742-7843.2009.00409.x
6. Relationship between dietary exposure and serum perfluorochemical (PFC) levels - a case study
Karrman A, Harada KH, Inoue K, Takasuga T, Ohi E, Koizumi A.
Environ Int. in press Jan, 35(4): 712-717, 2009 doi:10.1016/j.envint.2009.01.010
5. Fruit, vegetable and bean intake and mortality from cardiovascular disease among Japanese men and women: the JACC Study
Nagura J, Iso H, Watanabe Y, Maruyama K, Date C, Toyoshima H, Yamamoto A, Kikuchi S, Koizumi A, Kondo T, Wada Y, Inaba Y, Tamakoshi A; the JACC Study group.
Br J Nutr 13: 1-8, 2009 doi: 10.1017/S0007114508143586
4. Levels of N-acylethanolamines in O,O,S-trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice and potential anti-obesity, anti-diabetic effects of OOS-TMP in Akita and db/db mice
Huang L, Toyoshima M, Asakawa A, Inoue K, Harada K, Kinoshita T, Chen S, Koizumi A.
Pharmacol Biochem Behav. Accepted 10 Oct, 2008, 92(1):1-5, 2009 doi: 10.1016/j.pbb.2008.10.003
3. Cleft palate caused by perfluorooctane sulfonate is caused mainly by extrinsic factors
Era S, Harada KH, Toyoshima M, Inoue K, Minata M, Saito N, Takigawa T, Shiota K, Koizumi A.
Toxicology. Accepted 3 Nov, 2008, 256(1-2):42-47, 2009 doi: 10.1016/j.tox.2008.11.003
2. Polyfluorinated telomers in precipitation and surface water in an urban area of Japan
Mahmoud MA, Karrman A, Oono S, Harada KH, Koizumi A.
Chemosphere. Accepted 27 August, 2008, 74(3):467-472, 2009 doi: 10.1016/j.chemosphere.2008.08.029
1. Reconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans
Koizumi A, Azechi M, Shirasawa K, Saito N, Saito K, Shigehara N, Sakaue K, Shimizu Y, Baba H, Yasutake A, Harada K, Yoshinaga T, Ide-Ektessabi A.
Environ. Health Prev Med. Accepted 2 Oct, 2008, 14(1): 52-59, Jan 2009 doi: 10.1007/s12199-008-0059-4
総説・解説
2. Past, Present and Future of Environmental Specimen Banks
Koizumi A et al.
Environ. Health Prev Med. Accepted 12 Jul, 14(6): 307-18, Nov 2009 doi: 10.1007/s12199-009-0101-1
1. Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities
Harada KH and Koizumi A.
Environ. Health Prev Med. Accepted 1 Oct, 2008, 14(1): 7-19, Jan 2009 doi: 10.1007/s12199-008-0058-5
1. 特集・血栓症をめぐるわが国の疫学研究
山田茂樹、小泉昭夫. JACC研究(The Japan Collaborative Cohort Study)によるクモ膜下出血死亡リスク要因の網羅的解析
血栓と循環. 17巻2号 93-100, 2009
Editorial
1. Proposal of a new editorial policy for EHPM and Nippon Eiseigaku Zasshi
Koizumi A and Otsuki T
Environ. Health Prev Med. 14(4): 212-213, Jul 2009 doi: 10.1007/s12199-009-0093-x
2008
原著論文
11. Current levels of airborne polyfluorinated telomers in Japan
Oono S et al.
Chemosphere in press 1 July, 73(5): 932-937, 2008 doi: 10.1016/j.chemosphere.2008.06.069
10. Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women. The Japan Collaborative Cohort Study.
Ikehara S, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Wada Y, Inaba Y, Tamakoshi A; Japan Collaborative Cohort Study Group.
Stroke. available online Jul 10, 39:2936-2942, 2008 doi: 10.1161/STROKEAHA.108.520288
9. Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid [preprint]
Nakagawa H et al.
Basic Clin Pharmacol Toxicol. in press Sept 2007, 103 (1): 1-8, 2008 doi: 10.1111/j.1742-7843.2007.00155.x
8. Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer Risks
Umesawa M, Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Kondo T, Inaba Y, Tanabe N, Tamakoshi A, JACC Study Group
Am J Clin Nutr 88(1): 195-202, 2008
7. Autosomal dominant moyamoya disease maps to chromosome 17q25.3
Mineharu Y et al.
Neurology. in press Sept 2007, available online May, 70: 2357-2363, 2008 doi: 10.1212/01.wnl.0000291012.49986.f9
6. Ablation of Estrogen receptor alpha (ERa) prevents upregulation of POMC by leptin and insulin
Hirosawa M et al.
Biochem Biophys Res Commun. Accepted 16 Apr, published in 371 (2): 320-323, 2008 doi: 10.1016/j.bbrc.2008.04.073
5. Smoking status, sports participation and mortality from coronary heart disease.
Noda H, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Koizumi A, Kondo T, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A, JACC Study Group
Heart. 94(4):471-475, 2008 doi: 10.1136/hrt.2007.126458
4. Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23
Mineharu Y et al.
J Hum Genet. 53(4): 325-332, Apr 2008 doi: 10.1007/s10038-008-0255-5
3. The ubiquitous environmental pollutant perfluorooctanoic acid inhibits feeding behavior via peroxisome proliferator-activated receptor-a [preprint]
Asakawa A et al.
Int J Mol Med. 21(4): 439-446, Apr 2008 PMID: 18360689
2. Nephronophthisis complicated with hepatic fibrosis: an autopsy case with rupture of the splenic artery after renal transplantation
Tsukamoto T, Tanaka M, Komiya T, Ueda S, Takasu K, Takahara S, Koizumi A, Muso E.
Clin Exp Nephrol. 12(1): 82-88, Feb 2008
1. Survey of airborne polyfluorinated telomers in Keihan area, Japan [preprint]
Oono S et al.
Bull Environ Contam Toxicol. 80(2):102-106, Feb 2008 doi: 10.1007/s00128-007-9324-2
総説・解説
1. 特集・有機フッ素化合物PFOS・PFOAによる環境汚染
齋藤憲光, 原田浩二. PFOS,PFOA 物性、製造と分析法
原田浩二, 小泉昭夫. PFOS,PFOA 国内および国際的動向
小泉昭夫, 原田浩二. PFOS,PFOA 環境汚染の現状と健康リスク
環境技術. 37巻5号 306-318, 2008
2. 難分解性有機フッ素化合物による環境汚染と健康影響
原田浩二, 小泉昭夫
医学のあゆみ. 227巻2号 149, 2008
3. 遺伝疫学の社会還元 −全身性カルニシン欠損症を例に−
小泉昭夫
小児科 49巻12号:1871-1876. 2008年11月
4. もやもや病の遺伝要因の探索の現状
箸方宏州、劉万洋、峰晴陽平、井上佳代子、竹中勝信、池田秀敏、寶金清博、黒田敏、菊池顕次、木村充、瀧琢有、園部眞、伴貞彦、野垣秀和、半田明、菊田健一郎、高木康志、野崎和彦、橋本信夫、小泉昭夫
BRAIN and NERVE: 神経研究の進歩 60巻11号:1261-1269. 2008年11月
5. 専門医に求められる最新の知識 脳血管障害 家族性もやもや病
峰晴陽平、菊田健一郎、高木康志、野崎和彦、橋本信夫、小泉昭夫
脳神経外科速報 18巻7号:868-87. 2008年7月
6. 中国政府派遣研究員を受け入れて
小泉昭夫
JISTEC REPORT 69号:11. 2008年10月
2007
原著論文
14. Risk and Protective Factors Related to Mortality from Pneumonia among Middle-aged and Elderly Community Residents: The JACC Study
Inoue Y et al.
J Epidemiol. 17(6):194-202, 2007 doi: 10.2188/jea.17.194
13. Roles of neuropeptides in O,O,S-Trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice
Huang LF et al.
Biochem Biophys Res Commun. Accepted 31 Jul, Available online 10 Aug, 362(1):177-182, 2007 doi: 10.1016/j.bbrc.2007.07.174
12. Negative results of umu mutagenecity test of fluorotelomer alcohols and perfluorinated alkyl acids [preprint]
Oda Y et al.
Environ Health Prev Med. in press Jun, 12(5):217-219, 2007 doi: 10.1265/ehpm.12.217
11. ARMET is a soluble ER protein induced the unfolded protein response via ERSE-II element
Mizobuchi N, Hoseki J, Kubota H, Toyokuni S, Nozaki J, Naitoh M, Koizumi A, Nagata K
Cell Struct Funct. in press Mar, 32(1):41-50, 2007 doi: 10.1247/csf.07001
10. Biliary excretion and cerebrospinal fluid partition of perfluorooctanoate and perfluorooctane sulfonate in humans
Harada KH et al.
Environ Toxicol Pharmacol. Accepted on 9 Apr; 24(2):134-139, 2007 doi: 10.1016/j.etap.2007.04.003
9. Effects of perfluorooctane sulfonate on tracheal ciliary beating frequency in mice
Matsubara E et al.
Toxicology Accepted on 10 Apr; 236(3):190-198, 2007 doi: 10.1016/j.tox.2007.04.016
8. Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China.
Jin Y et al.
Tohoku J Exp Med. Accepted on 29 Mar 2007; 212(1): 63-70, Apr 2007 doi: 10.1620/tjem.212.63
7. Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus [preprint]
Asakawa A et al.
Int J Mol Med. 19(5): 733-739. May 2007 PMID: 17390077
6. Combination of Linkage and Association Studies for Brain Arteriovenous Malformation
Inoue S et al.
Stroke. Accepted on October 30, 2006; 38(4):1368-1370, 1 Apr 2007 doi: 10.1161/01.STR.0000260094.03782.59
5. Model-Based Linkage Analyses Confirm Chromosome 19q13.3 as a Susceptibility Locus for Intracranial Aneurysm
Mineharu Y et al.
Stroke. Accepted on November 7, 2006; 38(4):1174-1178, 1 Apr 2007 doi: 10.1161/01.STR.0000259657.73682.03
4. Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study.
Cui R, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Inaba Y, Tamakoshi A, JACC Study Group
Atherosclerosis. 2006 Sep Epub ahead of print; 194(2):415-420, 2007 doi: 10.1016/j.atherosclerosis.2006.08.022
3. Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system
Asakawa A et al.
Int J Mol Med. 19(4): 649-652. Apr 2007 PMID: 17334640
2. Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice
Toyoshima M et al.
Biochem Biophys Res Commun. Accepted 14 Nov, Available online 27 Nov 2006; 352(3):703-708, 19 Jan 2007 doi: 10.1016/j.bbrc.2006.11.076
1. Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan
Harada K et al.
Chemosphere in press 8 May, Available online 21 June 2006; 66(2):293-301, Jan 2007 doi: 10.1016/j.chemosphere.2006.05.010
1. 労働者のくも膜下出血予防に対する労働法制等と医学的知見との齟齬
湯木知史
季刊 労働法 2007 Dec; 219号 169-179
Correspondence
1. Analysis of published PKD1 gene sequence variants.
Gout AM; the ADPKD Gene Variant Consortium; Ravine D.
(Harris PC, Rossetti S, Peters D, Breuning M, Henske EP, Koizumi A, Inoue S, Shimizu Y, Thongnoppakhun W, Yenchitsomanus PT, Deltas C, Sandford R, Torra R, Turco AE, Jeffery S, Fontes M, Somlo S, Furu LM, Smulders YM, Mercier B, Ferec C, Burtey S, Pei Y, Kalaydjieva L, Bogdanova N, McCluskey M, Geon LJ, Wouters CH, Reiterova J, Stekrova J, San Millan JL, Aguiari G, Senno LD
)
Nat Genet 39(4): 427-428. Apr 2007 doi: 10.1038/ng0407-427
総説・解説
3. 遺伝子からみたくも膜下出血の病態
峰晴陽平、井上佳代子、野崎和彦、橋本信夫、小泉昭夫
分子脳血管病 6巻2号:141-149. 2007年4月
2. ヒト生体試料バンク -現状と課題
小泉昭夫. はじめに
井上佳代子. 環境汚染モニタリングのための生体試料バンク
井上悠輔. 生体試料バンクの倫理的課題-海外での規制立案をめぐる経験から
小泉昭夫. ヒト生体試料バンクの有効利用に向けて-バンクの抱える長期的課題
医学のあゆみ. 220巻10号 833-844, 2007
1. Annual Review腎臓 2007
【編】御手洗哲也・東原英二・秋澤忠男・五十嵐隆・金井好克, Jan 2007, 中外医学社
IV.間質・尿細管 2.アミノ酸尿症の遺伝子変異 〈小泉昭夫〉
2006
原著論文
16. Effects of perfluorooctane sulfonate on action potentials and currents in cultured rat cerebellar Purkinje cells
Harada KH et al.
Biochem Biophys Res Commun. Accepted 9 Oct 2006, 351(1):240-245, 8 December 2006 doi: 10.1016/j.bbrc.2006.10.038
15. Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: The JACC study
Cui R, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Inaba Y, Tamakoshi A, JACC Study Group
J Epidemiol 16 (5): 177-184 Sep 2006. doi: 10.2188/jea.16.177
14. Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting
Mineharu Y et al.
J Neurol Neurosurg Psychiatry. in press 9 Jun, Published Online First: 20 June 2006; 77(9): 1025-1029. 2006 doi: 10.1136/jnnp.2006.096040
13. The bioconcentration factor of perfluorooctane sulfonate is significantly larger than that of perfluorooctanoate in wild turtles (Trachemys scripta elegans and Chinemys reevesii turtles): an Ai river ecological study in Japan.
Morikawa A et al.
Ecotoxicol Environ Saf. in press 8 March 2005, Available online 25 July 2005; 65(1): 14-21 2006 doi:10.1016/j.ecoenv.2005.03.007
12. A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers
Fujino Y, Iso, H, Tamakoshi A, Inaba Y, Koizumi A, Kubo T, Yoshimura, T, for the JACC Study Group.
Am J Epidemiol 164(2):128-135 2006.doi: 10.1093/aje/kwj185
11. Levels and Concentration Ratios of Polychlorinated biphenyls and Polybrominated diphenyl ethers in Serum and Breast Milk in Japanese Mothers
Inoue K et al.
Environ Health Perspect in press 18 April, 114(8):1179-1185. Aug 2006 doi: 10.1289/ehp.9032
10. Quantitative survival model for short-term survival after adult-to-adult living donor liver transplantation
Tsunematsu I, Ogura Y, Inoue K, Koizumi A, Tanigawa N, Tanaka K
Liver Transpl. Published Online: 18 May 2006, 12(6): 904-911 doi: 10.1002/lt.20743
9. Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm. A Preliminary Study
Inoue K et al.
Circulation in press 17 April 2006, published April 25, 2006, 113(13): 2002 - 2010. doi: 10.1161/CIRCULATIONAHA.105.579326
8. Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 to Intracranial Aneurysm.
Mineharu Y et al.
Stroke in press 2 June 2005 published online March 30, 2006, 37: 1189 - 1194, 2006 doi: 10.1161/01.STR.0000217408.91389.4d
7. Large-Scale Evaluation of the Current Level of Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk from 13 Regions of Japan
Eslami B et al.
Chemosphere. in press 16 Sep, Available online 22 Nov 2005, 63(4): 554-561, 7 Apr 2006 doi:10.1016/j.chemosphere.2005.09.067
6. A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population
Takahashi I, Utsunomiya M, Inoue K, Takahashi T, Nozaki J, Wada Y, Takada G, Koizumi A
Tohoku J Exp Med. 208 (3): 255-259 Mar 2006. doi: 10.1620/tjem.208.255
5. Parental longevity and mortality amongst Japanese men and women: the JACC Study
Ikeda A, Iso H, Toyoshima H, Kondo T, Mizoue T, Koizumi A, Inaba Y, Tamakoshi A, JACC Study Group
J Intern Med 259(3): 285-295. Mar, 2006 doi:10.1111/j.1365-2796.2005.01609.x
4. Particle Size Distribution and Respiratory Deposition Estimates of Airborne Perfluorooctanoate and Perfluorooctanesulfonate in Kyoto Area, Japan
Harada K et al.
Bull Environ Contam Toxicol. in press Nov 2005, 76(2):306-310, 2006 doi: 10.1007/s00128-006-0922-1
3. Dietary Intake of Calcium in Relation to Mortality From Cardiovascular Disease. The JACC Study
Umesawa M, Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Kondo T, Inaba Y, Tanabe N, Tamakoshi A, JACC Study Group
Stroke Published online before print December 8, 2005, 37(1): 20-26, 2006 doi:10.1161/01.STR.0000195155.21143.38
2. Effects of perfluorinated amphiphiles on backward swimming in Paramecium caudatum
Matsubara E et al.
Biochem Biophys Res Commun. Accepted 9 November, Available online 16 November 2005, Published 13 January 2006 339(2): 554-561 doi:10.1016/j.bbrc.2005.11.048
1. A Nonsense Polymorphism (Y319X) of the Solute Carrier Family 6 Member 18 (SLC6A18) Gene is not associated with Hypertension and Blood Pressure in Japanese.
Eslami B et al.
Tohoku J Exp Med. in press 19 Oct 2005, published 2006 208(1): 25-31doi: 10.1620/tjem.208.25
総説・解説
1. 脳神経外科領域疾患の遺伝子解析
峰晴陽平、小泉昭夫
脳神経外科速報. 2006年5月号 May 16(5):416-425
2. 【社会でひとを育てる OJTを後押し】 社会健康医学における人材育成
小泉昭夫
労働の科学. 61巻8号 462-466, 2006
3. [脳血管障害各論 脳卒中症候を来す遺伝性疾患] 家族性脳動脈瘤
山田茂樹、野崎和彦、井上佳代子、小泉昭夫、橋本信夫
日本臨床 64巻 増刊8 インターベンション時代の脳卒中学(改訂第2版). 2006年11月 760-763
著書・訳書
1. 日本語版ハリソン内科学 第2版原著第16版
日本語版監修:福井次矢、黒川清 2006 May, メディカル・サイエンス・インターナショナル
小泉昭夫 監訳「Part16 中毒,薬物過剰投与,および有害生物による被害」.
[376章]小泉 昭夫 [377章]井上 純子

2005
原著論文
13. A prospective cohort study of employment status and motality from circulatory disorders among Japanese workers.
Fujino Y, Iso, H, Tamakoshi A, Inaba Y, Koizumi A, Kubo T, Yoshimura, T, for the JACC Study Group.
J Ocuup Health. 47 (6): 510-517 Dec 2005.doi: 10.1539/joh.47.510
12. Long-acting gonadotropin-releasing hormone analogue treatment for central precocious puberty in maternal uniparental disomy chromosome 14
Takahashi I, Takahashi T, Utsunomiya M, Takada G, Koizumi A
Tohoku J Exp Med. 207 (4): 333-338 DEC 2005. doi: 10.1620/tjem.207.333
11. Walking and Sports Participation and Mortality From Coronary Heart Disease and Stroke
Noda H, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Koizumi A, Kondo T, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A, the JACC Study Group
J Am Coll Cardiol 2005 46: 1761-1767. doi: 10.1016/j.jacc.2005.07.038 [Abstract]
10. Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface.
Yoshinaga T et al.
Biol Chem. 2005 Nov;386(11):1077-1085. doi: 10.1515/BC.2005.124
9. Renal clearances of perfluorooctane sulfonate and perfluorooctanoate in human, and their species-specific excretion.
Harada K et al.
Environ Res. Available online 18 January 2005, published Oct 2005, 99(2), 253-261. doi:10.1016/j.envres.2004.12.003
8. History of Blood Transfusion before 1990 Is a Risk Factor for Stroke and Cardiovascular Diseases: The Japan Collaborative Cohort Study (JACC Study).
Yamada S, Koizumi A, Iso H, Wada Y, Watanabe Y, Date C, Yamamoto A, Kikuchi S, Inaba Y, Kondo T, Toyoshima H, Tamakoshi A, JACC Study Group
Cerebrovasc Dis. 2005; 20(3):164-171 doi:10.1159/000087200
7. Assessment of human exposure to polychlorinated and polybrominated diphenyl ethers in Japan using early 1980s and mid 1990s archive samples.
Koizumi A et al.
Environ Res. Available online 22 January 2005, published 28 July 2005, 99(1): 31-39 doi:10.1016/j.envres.2004.12.003
6. Body Mass Index and Mortality From Cardiovascular Disease Among Japanese Men and Women. The JACC Study.
Cui R, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Wada Y, Inaba Y, Tamakoshi A, JACC Study Group
Stroke Available online May 26, 2005, Jul, 36(7):1377-1382. doi: 10.1161/01.STR.0000169925.57251.4e [Abstract]
5. Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic {beta}-cells via transcriptional activation.
Ueda K, Kawano J, Takeda K, Yujiri T, Tanabe K, Anno T, Akiyama M, Nozaki J, Yoshinaga T, Koizumi A, Shinoda K, Oka Y, Tanizawa Y.
Eur J Endocrinol. 2005 Jul;153(1):167-76.
4. Secular Trends and Geographical Variations in the Dietary Intake of Polybrominated Diphenyl Ethers (PBDEs) Using Archived Samples from the Early 1980s and Mid 1990s in Japan.
Wada Y et al.
J Occup Health. Accepted Feb, 15, Published Jun 2005, 47(3): 236-241 doi: 10.1539/joh.47.236
3. Effects of PFOS and PFOA on L-type Ca2+ currents in guinea-pig ventricular myocytes.
Harada K et al.
Biochem Biophys Res Commun. Accepted 31 January 2005, 329(2): 487-494 doi:10.1016/j.bbrc.2005.01.163
2. Airborne Perfluorooctanoate (PFOA) may be a Substantial Source Contamination in Kyoto Area, Japan
Harada K et al.
Bull Environ Contam Toxicol. 2005 Jan, 74(1):64-69
1. Smoking cessation and mortality from cardiovascular disease among Japanese men and women: the JACC Study.
Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, Kikuchi S, Koizumi A, Wada Y, Kondo T, Inaba Y, Tamakoshi A
Am J Epidemiol. 2005 Jan 15;161(2):170-9.
総説
1. Distributions of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in Japan and their toxicities
Nakayama S, et al.
Environ. Sci. in press. Nov 2005, 12(6): 293-313, 2005 [Abstract] PMID: 16609670
1. PFOS,PFOA問題の2005年までの動き
小泉昭夫, 原田浩二
MATERIAL STAGE(マテリアルステージ). 2005 Dec
2004
原著論文
1. Application of Human Reliability Analysis to Nursing Errors in Hospitals.
Inoue K et al.
Risk Anal. 2004 Dec 24(6):1459-1474 doi: 10.1111/j.0272-4332.2004.00542.x
2. A genome-wide scan for Japanese familial intracranial aneurysms; linkage to several chromosomal regions.
Yamada S et al.
Circulation. 2004 110 (24):3727-3733 doi: 10.1161/01.CIR.0000143077.23367.18
3. Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.
Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SRM, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A
Nat Genet. 2004 Aug 1 Published online, 36 (9): 999-1002 SEP 2004. doi: 10.1038/ng1405
4. Gender-related difference, geographical variation and time trend in dietary cadmium intake in Japan.
Watanabe T, Shimbo S, Nakatsuka H, Koizumi A, Higashikawa K, Matsuda-Inoguchi N, Ikeda M
Sci Total Environ. 2004 Aug 15;329(1-3):17-27.
5. Assessment of the environment using synchrotron radiation micro-beams.
Shirasawa K, Ide-Ektessabi A, Koizumi A, Azechi M, Sie S
J Electron Spectrosc. 2004 Jun; 134-40: 827-830.
6. The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in human serum over the last 25 years.
Harada K et al.
J Occup Health. 2004 Mar; 46(2): 141-147. doi: 10.1539/joh.46.141 [Full Text]
7. Biochemical hypoglycemia in female nurses during clinical shift work.
Inoue K et al.
Res Nurs Health. 2004 Mar; 27(2): 87-96.
8. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.
Nozaki J et al.
Genes Cells. 2004 Mar; 9(3):261-270.
9. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations in surface waters in Japan.
Saito N et al.
J Occup Health. 2004 Feb; 46(1):49-59 doi: 10.1539/joh.46.49
10. Application of synchrotron radiation microbeams to environmental monitoring.
Ide-Ektessabi A, Shirasawa K, Koizumi A, Azechi M
Nucl. Instr. Meth. Phys. Res. B. 2004 Jan; 213:761-765
11. Recommendation of occupational exposure limits (2004-2005)
Omae K, Endo G, Endo Y, Hanaoka T, Higashi T, Kawai T, Kawamoto T, Kishi R, Koizumi A, Kusaka Y, Misumi J, Nakaaki K, Sato A, Satoh H, Takahashi K, Takeuchi Y, Tomokuni K, Yano E
J Occup Health 46 (4): 329-344 JUL 2004.
1. 家族性脳動静脈奇形の遺伝子解析
竹中勝信, 依藤純子, 山田茂樹, 山川弘保, 阿部雅光, 田渕和雄, 小泉昭夫
脳神経外科ジャーナル. 2004 Dec; 13(12):837-845.
2. 脳神経外科疾患の責任遺伝子解析の概説
小泉昭夫・山田茂樹・宇都宮真木・井上佳代子・野崎和彦・竹中勝信・岩間亨・鈴木倫保・野村貞宏・依藤純子・山川弘保・阿部雅光・田渕和雄・松田昌之・橋本信夫.
脳神経外科. 2004 Dec; 32(12):1203-1213.
3. 健康被害に関するクライシスマネジメントにおける現行産業医制度の法的問題
湯木知史・箱崎幸也・吉永侃夫・小泉 昭夫.
産業衛生学雑誌(San Ei Shi). 2004 Sep; 46(5):159-167.[Full text]
4. 医療事故・ヒヤリ・ハット事例分析システムの開発と試行
井上佳代子・小泉 昭夫.
日本医師会雑誌(J Jpn Med Assoc). 2004 Feb; 131(4):517-524.
1. Snap shots of Dr Roy Walford as an active scientist and a guiding mentor.
Koizumi A.
Exp Gerontol. 2004 Jun; 39(6): 903-906.
1. 我国部分地区自来水和不同水体中的 PFOS汚染
(The status of perfluorooctane sulfonate (PFOS) pollution in tap water and different waters in partial areas of China)
金一和・劉暁・秦紅梅・麻懿馨・范新欧・張頴花・齋藤憲光・佐々木和明・小泉昭夫
中国環境科学. 2004 Apr; 24(2):166-169.
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2003
著書・訳書
1. 分子予防環境医学-生命科学研究の予防・環境医学への統合-
分子予防環境医学研究会 編 2003 Dec, 本の泉社
宇都宮真木、山田茂樹、小泉昭夫「分子疫学/EBM」:05-15.
原田浩二、井上佳代子、小泉昭夫「難分解性環境汚染物質」:638-649.
井上悠輔、小泉昭夫「遺伝情報管理システム」:674-686.
2. NEW予防医学・公衆衛生学
岸玲子、古野純典、小泉昭夫、大前和幸 編 2003 Oct, 南江堂
3. 日本語版ハリソン内科学原著第15版
日本語版監修:福井次矢、黒川清 2003 May, メディカル・サイエンス・インターナショナル
小泉昭夫 監訳「Part15 環境・職業上の有害因子」.
4. 遺伝子医学別冊/遺伝子医学の入門書 「これだけは知っておきたい遺伝子医学の基礎知識」
監修:本庶佑 編集:有井滋樹、武田俊一、平井久丸、三木哲郎 2003 Jan, メディカル ドゥ
井上悠輔、小泉昭夫「病気の原因遺伝子の単離のための戦略、疾患とフィールドの選択」.
原著論文
1. Risk factors for fatal subarachnoid hemorrhage: the Japan Collaborative Cohort Study.
Yamada S, et al.
Stroke. 2003 Dec 1(E-Pub ahead); 34(12):2781-7.
2. Impact of Airborne Perfluorooctane Sulfonate (PFOS) on the Human Body Burden and the Ecological System
Sasaki K, et al.
Bull Environ Contam Toxicol. 2003 Aug; 71(2):408-413. doi: 10.1007/s00128-003-0179-x
3. Perfluorooctane Sulfonate (PFOS) Concentrations in Surface Water in Japan
Saito N et al.
Arch Environ Contam Toxicol. 2003 Aug; 45 (2):149-158. doi: 10.1007/s00244-003-0163-9
4. Perfluorooctane sulfonate(PFOS) contamination of drinking water in the Tama River, Japan: Estimated effects on resident serum levels.
Harada K et al.
Bull Environ Contam Toxicol. 2003 Jul; 71(1):31-36. doi: 10.1007/s00128-003-0126-x
5. The mass screening group Evaluation of a mass screeing program for Lysinuric protein intolerance (LPI) in the northern part of Japan.
Koizumi A et al.
Genet Test. 2003 Spring;7(1):29-35.
6. Absence of linkage of familial intracranial aneurysms to 7q11 in highly aggregated Japanese families.
Yamada S et al.
Stroke. 2003 Apr;34(4):892-900.
7. A historical aspect of Lysinuric protein intolerance in a northern part of Iwate, Japan.
Inoue Y et al.
Human Biol. 2003 Feb;75(1):81-90. PMID: 12713148
8. The relationship between smoking habits and serum levels of 8-OHdG, oxidized LDL antibodies, Mn-SOD and carotenoids in rural Japanese residents.
Suzuki K et al.
J Epidemiol. 2003 Jan;13(1):29-37.
9. Recommendation of occupational exposure limits (2003-2004)
Omae K, Endo G, Endo Y, Hanaoka T, Higashi T, Kawai T, Kawamoto T, Kishi R, Koizumi A, Kusaka Y, Misumi J, Nakaaki K, Sato A, Satoh H, Takahashi K, Takeuchi Y, Tomokuni K, Yano E, Kayama F, Murata K, Nagano K, Nasu T, Takebayashi T, Takeshita T, Yokoyama K, Futatsuka M, Miyakita T, Nakagawa M, Okuno T, Shimizu E, Tsuruta H, Hara I, Horiguchi S, Ikeda M, Iwata H, Kagawa J, Kasuya M, Kimura K, Koshi S, Matsushita T, Nomiyama K, Nomura S, Sakurai H, Shima S, Suzuki T, Tanaka M, Tati M, Yamamoto T, Yamamura Y
J Occup Health 45 (4): 254-269 JUL 2003.
1. 遺伝子診断を用いたリジン尿性蛋白不耐症の新生児マススクリーニング
高砂子 祐平・坂井 博毅・塚谷 栄紀・五十嵐 司・伊東 邦郎・松井 正之・竹下 敏光・小林 有一・千田 勝一・利部 輝雄・荘司 裕・高田 五郎・石川 育成・松浦 範夫・井上 純子・小泉 昭夫.
日本医師会雑誌(J Jpn Med Assoc). 2003 Sep; 130(6):933-936.
2. 脳血管障害の遺伝子診断
竹中勝信, 坂井昇, 小泉昭夫
脳神経外科ジャーナル. 2003 Mar; 12(3):161-165.
1. 遺伝疫学的アプローチによるCommon Diseases のEvidence Based Health Careの確立
小泉昭夫
日本衞生學雜誌 2003 58(2),260-266. PMID: 12806964
1. インタビュールーム(537)小泉昭夫さん--医療ミス防止用のソフトを開発
小泉昭夫, 藤田敏伸
厚生福祉 2003 Apr; 5099, 11.
1. 人血清中全[弗气]辛[火完][石黄][酉先]基化合物汚染現状
(Perfluorooctance sufonate situation in serum of common population)
金一和・劉暁・張迅・李[丹彡]・張頴花・齋藤憲光・佐々木和明・小泉昭夫
中国公共衛生(CHINESE JOURNAL OF PUBLIC HEALTH). 2003 19(10):1200-1201.
2002
1. Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse.
Haseyama T et al.
Tohoku J Exp Med. 2002 Dec;198(4):233-44.
2. Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance.
Shoji Y et al.
Hum Mutat 2002 Nov;20(5):375-81
3. Characterization of gene expression profile associated with energy restriction-induced cold tolerance of heart.
Wada Y et al.
Microsc Res Technique (2002) 59; 313-316
4. Perceived mental stress and mortality from cardiovascular disease among Japanese men and women: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study).
Iso H, Date C, Yamamoto A, Toyoshima H, Tanabe N, Kikuchi S, Kondo T, Watanabe Y, Wada Y, Ishibashi T, Suzuki H, Koizumi A, Inaba Y, Tamakoshi A, Ohno Y
Circulation (2002) 106:1229-36
5. A congenic mouse and candidate gene at the chromosome 13 locus regulating bone density.
Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Matsumura T, Okudaira S, Mori M, Koizumi A, Nakamura T, Hosokawa M
Mamm Genome 13, 2002, 335-340.
6. Utilization of a Voluntary Reporting System in Quantitative Risk Assessment for Medical Tasks in a Hospital Setting-with Special Reference to Tasks Done by Nurses
Inoue K et al.
J Occup Health (2002) 44: 360-372. doi: 10.1539/joh.44.360
7. Age-Associated Cardiomyopathy in Heterozygous Carrier Mice of a Pathological Mutation of Carnitine Transporter Gene, OCTN2
E et al.
J Gerontol A Biol Sci Med Sci., July 1, 2002; 57(7): B270 - 278.
8. Mutation Analysis of PKD1 in Japanese Autosomal Dominant Polycystic Kidney Disease Patients.
Inoue S et al.
Human Mut. 2002, 19:622-628. doi: 10.1002/humu.10080
9. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M.
J Clin Invest.2002, 109; 525-532 doi: 10.1172/JCI200214550
10. Genetic epidemiology of hereditary hemorrhagic telagioectasia in a localcommunity in the northern part of Japan.
Dakeishi M et al.
Human Mut.2002 19; 140-148.
11. Recommendation of occupational exposure limits (2002-2003)
Sakurai H, Sakurai H, Endo G, Endo Y, Hanaoka T, Kagawa J, Kasuya M, Kawai T, Kishi R, Koizumi A, Kusaka Y, Misumi J, Nakaaki K, Omae K, Sato A, Satoh H, Takeuchi Y, Tomokuni K, Yano E, Higashi T, Kawamoto T, Kayama F, Yokoyama K, Takahashi K, Futatsuka M, Iwata H, Miyakita T, Nakagawa M, Okuno T, Shimizu E, Tanaka M, Tsuruta H, Hara I, Horiguchi S, Ikeda M, Ishinishi N, Kimura K, Koshi S, Matsushita T, Nomiyama K, Nomura S, Shima S, Suzuki T, Tati M, Yamamoto T, Yamamura Y.
J Occup Health 44 (4): 267-282 JUL 2002.
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